The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3- gamma, - delta and - zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor - CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] . It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

Mar 28, 2025 · CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

Mar 8, 2025 · Title: Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient. Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.

Aug 20, 2020 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR. Keywords: CAR-T therapy; Csk; ITAM; T cell receptor; TCR; cancer; cell persistence; cytokine release; p85; phosphorylation pattern; quantitative mass spectrometry. Copyright © 2020 Elsevier Inc.

CD3E is a prognostic marker in Breast invasive carcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Head and neck squamous cell carcinoma

Apr 12, 2024 · An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.

In this study, we examined the role of CD3ε ITAM-mediated signals in T cell development by genetically reconstituting CD3ε-deficient mice with transgenes encoding either wild-type or ITAM-mutant (signaling defective) forms of the protein.

Jul 29, 2020 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR.

Dec 27, 2024 · Clinical resource with information about CD3E, Immunodeficiency 18, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.