CD155 (cluster of differentiation 155), also known as the poliovirus receptor, is a protein that in humans is encoded by the PVR gene. [ 3 ] [ 4 ] It is a transmembrane protein that is involved in forming junctions between neighboring cells.

Cluster of differentiation (CD155), formerly identified as poliovirus receptor (PVR) and later as immunoglobulin molecule, is involved in cell adhesion, proliferation, invasion and migration. It is a surface protein expressed mostly on normal and transformed malignant cells.

Oct 1, 2018 · Poliovirus receptor (PVR, CD155), a member of the nectin-like family of proteins, is recently emerging as a promising target in immunotherapy that enhances the existing anti-tumor responses.

In this review we will focus on the roles of CD155 as a ligand for the activating receptor DNAM-1 regulating immune surveillance against cancer and as pro-oncogenic molecule favoring tumor proliferation, invasion and immune evasion.

Oct 1, 2023 · CD155 is highly expressed in a variety of tumors. CD155 binds to its receptors TIGIT, CD96, and CD226, leading to immune escape. CD155 can be used as an important potential therapeutic target.

4 days ago · Combining CD155 and anti-DNAM-1 pretreated alloNK did not affect survival and tumor control benefits seen with CD155 blockade alone. RNA microarray showed mice treated with alloNK and CD155 blockade had increased expression of cytotoxicity genes and the NKG2D ligand H60a, whereas mice treated with anti-DNAM-1 pretreated alloNK cells resulted in ...

CD155 overexpression promotes tumor cell invasion and migration, and is associated with tumor progression and poor prognosis. As the ligand for both costimulatory receptor CD226 and coinhibitory receptor TIGIT and CD96 on natural killer and T cells, CD155 seems to play a dual role in oncoimmunity.

CD155 is a single-span, glycosylated peptide with three immunoglobulin-like ectodomains (NH2-V-C2-C2). You might find these chapters and articles relevant to this topic.

CD155, originally discovered as the poliovirus receptor, is an immunoglobulin superfamily adhesion molecule involved in cell adhesion and migration, proliferation, and immune modulation.17 Acute myeloid leukemia, multiple myeloma, neuroblastoma, fibrosarcoma, glioblastoma, melanoma, prostate cancer, renal cell cancer, pancreatic carcinomas ...

Apr 20, 2024 · CD155 monoclonal antibody has been investigated as a strategy for enhancing tumor control in experimental settings. CD155 antibody treatment reduced metastatic burden in immunocompetent mice [124], and inhibited tumor cell migration and invasion in vitro [124].