CD15 is a carbohydrate-based molecule that is expressed in the granulocytic series, as well as in monocytes, macrophages/histiocytes, and various epithelial cells. It is not expressed in erythroid precursors, B-cells, T-cells, or NK cells, but it may be expressed in Reed-Sternberg cells and activated T-cells.

Oct 19, 2008 · The glycan determinant CD15 (also known as Lewis x, or Lex) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.

Apr 28, 2022 · CD15 (Lewis X/Lex) is a fucosyl (3-fucosly-N-acetyl-lactosamine) moiety found on membrane proteins of various cancer cells. These cancers include renal cancer, prostate and bladder cancers, acute leukaemias, hepatocellular carcinoma, breast cancer and melanoma.

CD15 is a haemopoietic differentiation antigen expressed on most terminally differentiated myeloid cells including granulocytes, eosinophils, mast cells, monocytes/macrophages, and Langerhans’ cells.

Our results unveil a new paradigm, demonstrating a critical role for post-Golgi membrane glycosidase activity in the “biosynthesis” of a key glycan determinant. The Lewis x (Le x) antigen, or CD15, is a cell surface glycan consisting of a trisaccharide with the …

Here we show that CD15s (sialyl Lewis x) is specifically expressed by activated, terminally differentiated, and most suppressive FOXP3 high Treg cells, allowing their separation from nonsuppressive FOXP3 + CD4 + T cells secreting inflammatory cytokines.

An apparent molecular mass of about 200 kDa was detected by anti-CD15 mAb in all subpopulations, including CD4 + T cells, CD8 + T cells, B cells (CD19 +), monocytes (CD14 +), NK cells (CD56 +), and mature granulocytes.

Apr 28, 2022 · The CD15s expression pattern allows for discrimination between suppressive eTreg cells (CD15 +) and cytokine-secreting non-Treg cells. CD4 + CD15 + cell depletion from the CD4 + population evokes and enhances both anticancer (targeting NY-ESO-1) and antiviral (anti-CMV) immune responses .

The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells. Despite broad interest in this structure, the mechanisms underlying CD15 expression remain relatively uncharacterized.

CD15 is a haemopoietic differentiation antigen expressed on most terminally differentiated myeloid cells including granulocytes, eosinophils, mast cells, monocytes/macrophages, and Langerhans’ cells. Haemopoietic progenitor cells and myeloblasts do not express CD15.