The common gamma chain (γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at …

Nov 17, 2024 · CD132, also known as IL-2RG or common γ chain (γc) cytokine receptor, is the common subunit of γc cytokines, including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and...

IL-2 and its receptor have key roles in key functions of the immune system, tolerance and immunity, primarily via their direct effects on T cells.

Mar 15, 2001 · IL-2R is made up of three chains, α (CD25), β (CD122), and γ (CD132), of which only the α-chain is specific for IL-2. Signaling takes place mainly via CD122. Activated T cells …

Recent studies have shown that a wide range of membrane proteins have labile disulfide bonds including CD132, the common gamma chain of the receptors for several cytokines including …

Mutations of the IL2RG gene, which encodes for the interleukin-2 receptor common gamma chain (γC, CD132), can lead to X-linked severe combined immunodeficiency (X-SCID) associated …

HEK-Blue™ IL-2 and HEK-Blue™ CD122/CD132 cells were engineered from the human embryonic kidney HEK 293 cell line to detect bioactive interleukin-2 (IL-2) and interleukin-15 …

Objective: Activated macrophages upregulate surface expression of common cytokine receptor gamma chains (gammac, CD132), triggering of which induces secretion of proinflammatory …

Jan 15, 2015 · We observed that anti-CD132 monoclonal antibody (mAb) reduced acute GVHD potently with respect to survival, production of tumor necrosis factor, interferon-γ, and IL-6, …

Jun 15, 2017 · By combining an increased affinity for CD122 and an impaired recruitment of CD132, we have generated an original molecule named IL-2Rβ/γ (CD122/CD132) inhibitor …