Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. [5] . Also known as CD122; IL15RB; P70-75. [5] The interleukin 2 receptor, which is involved in T …

IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or …

CD122 expression was increased at distant memory time points where CD122 + T cells are increasingly of a T CM phenotype (Figure 1H). These findings suggest an important role for …

Here, we show that the availability of IL-2Rβ (CD122), which is a receptor subunit shared by IL-2 and IL-15, affects both the cytokine responsiveness and the LIP of naïve CD4 T cells in the …

CD8+CD122+ T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve …

Jan 25, 2018 · We find that in vivo administration of an anti-CD122 mAb (CD122 blockade) restores immune tolerance in nonobese diabetic (NOD) mice via multiple mechanisms. First, …

Oct 1, 2018 · Here we demonstrate that costimulation-independent T cell alloreactivity relies on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. Combined costimulatory …

Oct 19, 2015 · Human CD8 (+)CXCR3 (+) T-cells are the equivalent of murine CD8 (+)CD122 (+) Tregs and also exhibit central memory phenotypes. In this mini-review article, we will …

Oct 15, 2024 · CD122 plays a central role in regulating T cell responses, making it a key target in both cancer and autoimmune immunotherapies. Through careful modulation of CD122 …

May 5, 2014 · In this review, we summarize the significant progress in this promising field of CD8 + CD122 + Treg research and discuss their phenotypes, suppressive roles in autoimmunity …