Sep 20, 2021 · 33kd phosphoprotein with 3 hydrophobic regions that traverse the cell membrane, creating a structure similar to an ion channel that allows for the influx of calcium required for cell activation Initially expressed on B cells after CD19 / CD10 expression and before CD21 / CD22 and surface immunoglobulin expression; retained on mature B cells ...

Mar 26, 2025 · Bone & joints: AE1 / AE3 BCOR brachyury CD1a CD68 CD99 CD138 CIC-DUX4 ERG FLI1 GRM1 (pending) H3.3 G34W (H3F3A) H3K36M (pending) MDM2 MUM1 NKX2.2 (pending) S100 SATB2 SOX9

Jan 30, 2025 · MCL cells express CD5 and cyclin D1 (CCND1) due to t(11;14) translocation, which is absent in CLL cells (Nat Rev Dis Primers 2017;3:17008) CD5+ / SOX11+ / Cyclin D1- large cell lymphoma favors pleomorphic mantle cell lymphoma (Mod Pathol 2024;37:100405, Am J Surg Pathol 2012;36:214)

May 5, 2022 · Stains & CD markers Cytokeratin AE1 / AE3 ... AE3 detects the high molecular weight cytokeratins 1, 2, 3 ...

CD30 gene is located at 1p36 . Close to TNFR2 and OX40 Molecular weight of the protein: 120 kD Mature form of CD30 protein is processed from a precursor weighing 84 kD and during transit in the Golgi complex gains weight through glycosylation

Mar 26, 2025 · Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151)

Mar 29, 2025 · Lymph node, right cervical excision: Nodular lymphocyte predominant Hodgkin lymphoma (see comment) Comment: There is total replacement of the nodal architecture by expansive vague nodules of small lymphocytes with sparse, relatively large tumor cells with multilobulated or round nucleus, thin nuclear membrane, finely granular chromatin and …

Jun 13, 2024 · Involved in cell proliferation, migration, adhesion and angiogenesis with loss of CD138 expression leading to enhanced motility and invasion of neoplastic cells (Oncotarget 2015;6:28693)

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), with marked enhancement in specificity when used alongside TCF4, CD4, CD56, TCL1 and CD303, though CD303 can be negative in up to 56% (Am J Surg Pathol 2019;43:1429, Am J Surg Pathol 2014;38:673, Haematologica 2021;106:1047, Blood Adv 2019;3:4238)

Mar 19, 2024 · CD Markers - CD43. T/NK cell lymphomas - anaplastic large cell (variable), CD4+/CD56+ hematodermic neoplasm / blastic NK (Am J Surg Pathol 2005;29:1274), hepatosplenic gamma-delta T cell, NK/T cell-nasal type (96%, Hum Pathol 2004;35:86), peripheral T cell, subcutaneous panniculitis-like