In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers , which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in ...

CD18 is a 95 kDa glycoprotein that is a subunit of LFA-1. It consists of extracellular, transmembrane, and cytoplasmic domains, with potential glycosylation sites and cysteines for structural stability.

These studies examined the role of CD18 in regulating neutrophil production and determined whether the defects in neutrophil production that are observed in CD18 deficiency persist in the presence of wild type (WT) leukocytes that confer host protection.

It encodes the common beta 2 integrin subunit (CD18), which is necessary for the expression of lymphocyte function-associated antigen 1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18). Variants in this gene are the underlying cause for the autosomal recessive leukocyte adhesion deficiency type 1.

Dec 15, 2005 · We show that CD18 −/− mice demonstrate a propensity to autoimmunity. Absence of CD18 led to diminished CD4 + CD25 + T cell numbers and affected both thymic and peripheral development of these cells.

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation.

Sep 23, 2009 · CD18 is the common β-subunit of lymphocyte function-associated antigen-1 (LFA-1) (CD11a/CD18), Mac-1 (CD11b/CD18), and P150,95 (CD11c/CD18), proteins that are expressed on lymphocytes, monocytes/macrophages, and neutrophils, respectively.

Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, αMβ2 ...

Leukocyte Adhesion Deficiency-I (LAD-I) is a rare, autosomal recessive pediatric disease caused by a mutation of the ITGB2 gene that encodes for the Beta-2 Integrin component CD18. CD18 is a key protein that facilitates leukocyte adhesion and enables their extravasation from blood vessels to combat infections.

May 1, 2015 · The β 2 integrins (CD11/CD18) are heterodimeric leukocyte adhesion molecules expressed on hematopoietic cells. The role of T cell-intrinsic CD18 in trafficking of naïve T cells to secondary lymphoid organs, and in antigen-dependent T cell activation in vitro and in vivo has been well-defined.