The core binding factor (CBF) transcription factor is somewhat unique in that it is composed of a DNA binding RUNX subunit (RUNX1, 2, or 3) and a non-DNA binding CBFβ subunit, which modulates RUNX protein activity by modulating the auto-inhibition of the RUNX subunits.

We review how alterations to RUNX/CBFβ function contextually ascribe to breast cancer subtypes and discuss how the in vitro analyses and mouse model systems have contributed to our current understanding of these proteins in the pathogenesis of this complex set of diseases.

These findings indicate that Cbfb is required for skeletal development by regulating chondrocyte differentiation and proliferation and osteoblast differentiation; that Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb ...

CBFβ enhances DNA binding of RUNX subunits by relieving auto-inhibition. Both RUNX1 and CBFβ are frequently mutated in human leukemia. More recently, RUNX proteins have been shown to be key players in epithelial cancers, suggesting the …

Feb 18, 2021 · We demonstrated that high, low or null expression of IRF8 in hematopoietic progenitor cells promotes differentiation toward type 1 conventional DCs, Ly6C + monocytes or neutrophils, respectively,...

Oct 16, 2009 · FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here, we showed that Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune …

May 5, 2014 · To understand the molecular mechanism by which Runx proteins and Cbfβ regulate cell fate decisions in BM progenitors, we purified LSK cells and GMPs from Cbfb-CKO and control mice and performed gene expression analysis.

Jan 1, 2015 · Core binding factor β (Cbfb) forms a heterodimer with Runx family proteins and enhances their DNA-binding capacity. In Cbfb conditional knockout mice in osteoblast and chondrocyte lineages, the differentiation of chondrocytes and osteoblasts is inhibited.

Nov 18, 2002 · The fusion allele maintains sufficient function in hematopoietic cells to bypass the early embryonic lethality, and identifies a new role for Cbfb in bone development.

Aug 1, 2006 · Runx2 and Cbfβ are essential for skeletal development during the embryonic stage. Runx2 has two isoforms with different N-termini. We examined the functions of the Runx2 isoforms and Cbfβ in postnatal bone development.