Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, [5] critical to the apoptotic pathway found in many tissues. [6] Caspase-9 homologs have been identified in all mammals for which they are known to exist, such as …

Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.

Apr 4, 2017 · As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thoug …

Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme.

Jul 8, 2021 · Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.

Feb 9, 2025 · caspase-9 activation in human disease can play a prominent role in localized cellular degenerative processes without causing nuclear or cell death. Low-dose 5-aza-2'-deoxycytidine (DAC) induced enhancement of apoptosis mediated by Adenovirus-p53 infection, and ectopic overexpression of procaspase-9.

Mar 3, 2018 · In this work we show that the CARD is involved in physical interactions with the catalytic core of caspase-9 in the absence of the apoptosome; this interaction requires a properly formed caspase-9 active site. The active sites of caspases …

Caspase-9 is the upstream caspase that is activated when cytochrome c is released from the mitochondria in response to various forms of stress or death signals.

Feb 4, 2017 · Caspase-9 is essential to eliminate cells by executing apoptotic death early in development stage as it is indispensable to inhibit proliferative diseases through the continuous removal of irreparable cells in the lifecycle.

Jul 9, 2013 · Caspase-9 can cleave and activate Bid, caspase-7 and caspase-3. tBid can remodel the mitochondria and make conditions favorable for ROS production, which is enhanced by caspase-7 and inhibited by caspase-3.