Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs [5] have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.

Caspase-8 hampers pro-inflammatory gene expression induced by the cytosolic RNA sensor retinoic acid-inducible gene I (RIG-I) through cleavage of RIPK1, which is recruited to a complex of RIG-I and its adapter molecule mitochondrial antiviral signaling protein (MAVS) on mitochondria .

Mar 30, 2025 · CASP8 (Caspase 8) is a Protein Coding gene. Diseases associated with CASP8 include Caspase 8 Deficiency and Hepatocellular Carcinoma. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

Caspase-8 is the initiator caspase of extrinsic apoptosis 1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality³, which can be rescued by deletion of either Ripk3 or Mlkl^4-6.

Aberrant expression of caspase-8 is closely associated with the development and progression of a range of inflammatory diseases, including immune system disorders, neurodegenerative diseases (NDDs), sepsis, and cancer.

In this review, we discuss the emerging crosstalk between cell death and innate immune cell inflammatory signalling, particularly focusing on novel non-apoptotic functions of caspase-8. We also highlight the growing number of autoinflammatory diseases that are associated with enhanced inflammasome function.

Jan 21, 2022 · Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in...

Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R.

Oct 1, 2021 · Cysteinyl aspartate specific proteinase (Caspase)-8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells. With the continuous exploration of the types of programmed cell death, an increasing number of studies have confirmed that caspas …

Nov 13, 2019 · Caspase-8 is a protease with both pro-death and pro-survival functions: it mediates apoptosis induced by death receptors such as TNFR11, and suppresses necroptosis mediated by the kinase RIPK3...