Caspase-1 therefore plays a fundamental role in the innate immune system. The enzyme is responsible for processing cytokines such as pro-ILβ and pro-IL18, as well as secreting them. [22] Caspase-4 and -5 in humans, and Caspase-11 in mice have a unique role as a receptor, whereby it binds to LPS, a molecule abundant in gram negative bacteria ...

Caspases are key regulators of apoptosis and inflammation. Insufficient caspase activation can promote tumorigenesis or infection; hyperactivation can promote neurodegeneration or inflammatory conditions.

Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in ...

Jun 23, 2023 · Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death. Caspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflamm …

May 12, 2017 · The human caspase family is divided into three main groups, primarily based on sequence similarity and biological function. 15 Group I comprises the inflammatory caspases-1, -4, and -5...

Caspase-11 was the first enzyme discovered to participate in a non-canonical or non-caspase-1 mediated inflammasome as a response to gram-negative bacteria. This then led to the discovery of caspase-11’s proposed role as direct sensor of intracellular LPS from gram-negative bacteria during macrophage-mediated inflammatory responses [ 60 , 61 ].

Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.

Caspase refers to a family of cysteine proteases that are Ced-3 homologues and play a crucial role in apoptosis. They are initially produced as inactive proforms and become active after being cleaved. Caspase-3, having the highest similarity to Ced-3, is considered the main effector in apoptosis and cleaves multiple apoptosis substrates.

Jun 18, 2019 · Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years.

Dysregulation of caspases features prominently in many human diseases, including cancer, autoimmunity, and neurodegenerative disorders, and increasing evidence shows that altering caspase activity can confer therapeutic benefits.