Mar 10, 2020 · Repetitive or prolonged increase in intracellular Ca 2+ is required for the calcineurin-mediated dephosphorylation of the nuclear factor of an activated T cell (NFAT). …

After Ca 2+ activates CaN through CaM, CaN dephosphorylates NFAT and exposes the nuclear localization sequence to cause its nuclear translocation. 91 In the nucleus, NFAT acts as a …

Here, we review the role of the Ca 2+ -calcineurin–NFAT signaling pathway in health and diseases, focusing on the STIM and Orai1, and discuss the deregulated calcium-mediated …

In this review, we summarize the emerging evidence that deficient CaN/NFAT could contribute to brain degeneration in AD. In healthy adults, CaN is widely expressed throughout the brain, …

Sep 1, 2023 · Activated CaN can cause NFAT dephosphorylation of multiple residues in the N-terminal regulatory region, NHR (NFAT homology region), enhance the affinity of NFAT to the …

Jan 1, 2007 · Nuclear factor of activated T cells (NFAT) can bind DNA in multiple configurations, each eliciting a distinct transcriptional programme characteristic of a distinct cellular response.

Apr 19, 2002 · Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes …

However, little is known about the molecular basis of the CaN/NFAT pathway involved in KD. Therefore, in our study we investigate the role of Ca2+/CaN/NFAT signaling pathway in …

Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and …

Aug 20, 2010 · This Review describes recent insights into the NFAT-mediated regulation of distinct immune cells and details our increasing understanding of the importance of the NFAT …