May 20, 2010 · Conclusions: We revealed that caffeine inhibits cell proliferation through cAMP/PTEN/Akt inhibition signaling pathway in the sarcoma cells. We elucidated a novel molecular mechanism by which caffeine induces apoptosis in sarcoma cells.

Jun 1, 2018 · The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism.

In this study, increased cAMP enhanced PTEN activity and inhibited neutrophil phagocytosis. PTEN was first identified as a tumor suppressor gene in 1997, and subsequently was found to be negative regulator of cell growth and proliferation. It is …

Jan 17, 2024 · Cyclic adenosine monophosphate (cAMP) is a second messenger that has pleiotropic effects on the TME. The downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), exchange protein activated by cAMP (EPAC) and ion channels.

Nov 17, 2010 · Our results show that intraocular inflammation, deletion of the PTEN gene, and elevation of intracellular cAMP exert complementary effects that together enable RGCs to regenerate axons all the way from just behind the eye to the diencephalon in a few weeks.

In this review, we summarize recent advances in PTEN-membrane interactions and methods useful in addressing PTEN function. Keywords: Dictyostelium, PIP3, Membrane, Mutation. 1. Introduction. The PIP3 phosphatase, PTEN, converts PIP3 to PIP2.

Specific inhibition of phosphatase and tensin homolog (PTEN) enzyme attenuated the inhibition of neutrophil phagocytosis by PGE2, and both PGE2 and increased intracellular cAMP increased neutrophil PTEN activity, which was associated with decreased PTEN phosphorylation.

Jul 7, 2013 · Down-regulating PTEN expression in Xenopus laevis spinal neurons selectively abolished growth cone chemorepulsion but permitted chemoattraction. These findings persisted during cAMP-dependent switching of turning behaviors.

Jun 15, 2011 · In this study, we investigated the role of PTEN in cAMP-mediated growth inhibition. B92 rat glial cells were treated with 2 different cAMP stimulatory agents, a phosphodiesterase (PDE) inhibitor and a β-adrenoceptor agonist.

Jul 29, 2019 · Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, highlighted by the findings that...