比较G蛋白耦联受体介导的几种信号通路之间的异同？ - 知乎
结合gprc的主要是camp, ip3 和 dag，pka, pkc, plc和pi3k等也涉及了gprc的下游调控。 在这里我列举几个较为重要的：腺苷酸环化酶-cAMP-PKA、磷脂酶C（IP3-Ca2+、DAG-PKC）、离子通 …
Protein kinase C - Wikipedia
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through …
Different roles of cAMP/PKA and PKC signaling in regulating ...
Dec 1, 2018 · These data suggest that cAMP/PKA and PKC signaling have opposite effects on PGE 2 and progesterone synthesis in FSHR cells. We propose that this PKA and PKC …
Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An ...
Jun 29, 2005 · We found that, in cultured DRG neurons, signaling from cAMP to PKCϵ is not mediated by PKA but by the recently identified cAMP-activated guanine exchange factor Epac. …
cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic ... - eLife
Apr 26, 2023 · Presynaptic cAMP−EPAC−PKCε signaling cascade induces a previously unidentified threonine phosphorylation of RIM1α, and thereby initiates the assembly of the …
Cardiac cAMP-PKA Signaling Compartmentalization in …
As cAMP signaling is a key regulator of cardiac physiology, this review aims at describing molecular events that mediate cAMP signaling compartmentalization in cardiomyocytes under …
Modulatory effects of cAMP and PKC activation on gap junctional ...
Jan 15, 2010 · We investigated the effects of the signaling molecules, cyclic AMP (cAMP) and protein-kinase C (PKC), on gap junctional intercellular communication (GJIC) between thymic …
PKC-α-dependent augmentation of cAMP and CREB …
Nov 11, 2015 · In vitro data indicate that CD renin is augmented by AT 1 R activation through protein kinase C (PKC), but the exact mechanisms are unknown. We hypothesize that ANG II …
cAMP-induced PKCζ activation increases functional CXCR4 …
Feb 1, 2006 · We report here that functional expression of the chemokine receptor CXCR4 on human immature CD34 + hematopoietic progenitors was increased as a result of sustained …
Complex roles of cAMP-PKA-CREB signaling in cancer
Nov 24, 2020 · Aberrant cAMP-PKA signaling is involved in various types of human tumors. Especially, cAMP signaling may have both tumor-suppressive and tumor-promoting roles …