A calpain (/ ˈkælpeɪn /; [1] EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium -dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database.

May 1, 2021 · Calpains are calcium-dependent cysteine proteases. The members of the calpain family can have a classical or a non-classical structural organisation. Calpains as proteases require a number of mechanisms to control their activity from spatio-temporal modifications of expression to changes in molecular conformation.

Calpains represent a family of neutral, calcium-dependent proteases, which modify the function of their target proteins by partial truncation. These proteases have been implicated in numerous cell functions, including cell division, proliferation, migration, and death.

Jun 9, 2005 · Calpains are Ca 2+ -dependent cysteine proteases (proteolytic enzymes with cysteine in the catalytic site) that modulate cellular function. In humans, 14 independent genes encode members of the...

Aug 21, 2021 · Calpain is a conserved family of calcium-dependent, cytosolic, neutral cysteine proteases. The best characterized members of the family are the ubiquitously expressed calpain 1 and calpain 2. They perform controlled proteolysis of their target proteins.

Calpains are a 15-member class of calcium activated nonlysosomal neutral proteases which are involved in a broad range of cellular function. Calpains are usually localized to the cytosol and within mitochondria. Calpastatin is an endogenous protein that specifically binds to …

Aug 17, 2021 · Calpains are evolutionarily conserved and widely expressed Ca 2+ -activated cysteine proteases that act at neutral pH. The activity of calpains is tightly regulated, given that their abnormal activation can have deleterious effects leading to …

The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only known function is to inhibit the two calpains.

Calpain is a calcium-dependent protease that plays a role in activating TGase 1 in vivo. It is also involved in proteolytic processes related to cataract formation, potentially leading to the activation of TGase 1 and the formation of novel protein aggregates with pathogenic implications.

Apr 21, 2011 · The calpains are a family of cysteine proteases that catalyse the controlled proteolysis of a large number of specific substrates. Although the calpain family consists of more than ten members,...