Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). [2]

Calcineurin (CaN) is a unique calcium (Ca 2+) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca 2+ level.

Calcineurin is a eukaryotic Ca (2+)- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca (2+)-binding subunit, cal …

Aug 28, 2020 · Calcineurin is activated by increases in intracellular calcium concentrations, a process that requires the calcium sensing protein calmodulin binding to an intrinsically disordered regulatory domain in the phosphatase.

Aug 28, 2020 · Calcineurin is activated by increases in intracellular calcium concentrations, a process that requires the calcium sensing protein calmodulin binding to an intrinsically disordered regulatory domain in the phosphatase. Despite having been studied for around four decades, the activation of calcineurin is not fully understood.

Calcineurin is composed of two subunits: calcineurin A (61,000 Mr) which interacts with calmodulin in a Ca2+-dependent fashion, and calcineurin B (15,000 Mr) which binds Ca2+.

Calcineurin is a calmodulin-dependent serine/threonine phosphatase, consists of the catalytic subunit calcineurin A and a regulatory subunit, calcineurin B. In mammals, there are three known isoforms of calcineurin A, CnAα, CnAβ, and CnAγ, and two isoforms of …

Jan 10, 2000 · Calcineurin is a eukaryotic Ca2+- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A, which contains an act...

Calcineurin is a serine-threonine specific Ca (2+)-calmodulin-activated protein phosphatase that is conserved from yeast to humans. Remarkably, this enzyme is the common target for two novel and structurally unrelated immunosuppressive antifungal drugs, cyclosporin A and FK506.

Jun 21, 2005 · Calcineurin is a phosphoprotein serine/threonine phosphatase, activated physiologically by Ca 2+ –calmodulin. In plain language, calcineurin couples intracellular Ca 2+ to dephosphorylation of selected substrates.