Calbindin contains 4 active calcium-binding domains, and 2 modified domains that have lost their calcium-binding capacity. Calbindin acts as a calcium buffer and calcium sensor and can hold four Ca 2+ in the EF-hands of loops EF1, EF3, EF4 and EF5.

Calbindin is a calcium-binding protein found in certain neurons of the central nervous system. Its main role is to regulate the levels of intracellular calcium, which is crucial for the survival of neurons. It is also influenced by steroid hormones, including adrenal corticosteroids.

Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis.

Calbindin was found to block apoptosis in osteocytic and osteoblastic cells. Our findings suggest that calbindin is capable of directly inhibiting the activity of caspase-3, a common downstream effector of multiple apoptotic signaling pathways, and that this inhibition results in an inhibition of tumor necrosis factor (TNFalpha) and ...

Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). [5]

These proteins and neuropeptides differentiate GABAergic neurons into discrete subpopulations performing different roles in the inhibitory mechanism of the amygdala. Calbindin (CB), parvalbumin (PV) and calretinin (CR) are usually used to mark these subpopulations in the amygdala [37,38].

Jul 7, 2021 · Calbindin, a major Ca 2+ buffer in dentate granule cells (GCs), plays a critical role in shaping Ca 2+ signals, yet how it regulates neuronal function remains largely unknown.

Calbindin, a high-affinity calcium-binding protein, is involved in calcium buffering and transport in neurons. It has been shown to inhibit apoptosis and caspase-3 activity stimulated by presenilin 1 and 2 in AD.

Calbindin (also called cholecalcin, or vitamin D-dependent calcium-binding protein) is a vitamin D-dependent protein that binds calcium with high affinity (the calcium-binding regions are homologous to those of the calmodulin family), constituting approximately 2% of duodenal mucosal cell protein (found only in high amounts in the duodenum) in ...

The calcium-binding proteins parvalbumin and calbindin are expressed in neuronal populations regulating brain networks involved in spatial navigation, memory processes, and social interactions. Information about the numbers of these neurons across ...