Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial cells via bacterial type IV secretion, where it undergoes ...

Jul 14, 2016 · Using a type IV secretion system (Cag-pilus), H. pylori delivers CagA across both bacterial and host cell membranes into gastric epithelial cells. Translocation requires integrin α 5 β 1 and phosphatidylserine. Upon delivery, members of the oncogenic c-SRC and c-ABL tyrosine kinases can phosphorylate CagA at EPIYA and EPIYT sequences.

Chronic infection with Helicobacter pylori cagA -positive strains is the strongest risk factor for gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the bacterial type IV secretion system.

Several virulence factors, including cytotoxin-associated gene A (CagA), which is translocated into the gastric epithelium via the type 4 secretory system (T4SS), have been indicated to play a vital role in disease development.

The major pathological feature of H. pylori infection is due to the activity of the cytotoxin-associated gene A (CagA), a 125-140 kDa protein encoded by the cag pathogenicity island (cagPAI). CagA is also known as the first bacterial onco-protein, ranking the H. pylori-mediated adenocarcinoma as the second most deadly cancer type worldwide.

CagA (cytotoxin-associated antigen A) is a major virulence factor for H. pylori, an oncoprotein that is encoded by the cagA gene. Bacterial strains with the cagA gene are associated with the ability to cause ulcers, MALT lymphomas, and gastric cancer.

In this chapter we will focus on the functions that are encoded by a 40-kb chromosomal region with the features of a PAI (1, 9, 54). The H. pylori PAI was originally named cag (cytotoxin-associated gene) since it was thought to be associated …

Mar 17, 2016 · CagA is one of the most studied pathogenicity factors of the bacterial pathogen Helicobacter pylori. It is injected into host cells via the H. pylori cag -Type IV secretion system. Due to...

Jan 18, 2024 · Helicobacter pylori CagA is the first and only bacterial oncoprotein etiologically associated with human cancer. Upon delivery into gastric epithelial cells via bacterial type IV secretion, CagA acts as a pathogenic/pro-oncogenic scaffold that interacts with and...

Oct 29, 2018 · Whole genome sequence analysis revealed that Hp_TH2099 belongs to the hpAsia2 cluster and possesses ABC-type Western CagA, which contains hitherto unreported variations in both EPIYA-C and CM...