Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene. CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes. Like most of the cytochrome P450, the CYP3A5 is expressed in the prostate and the liver. [5] .

We recently tested you for the CYP3A5 gene. This info sheet explains the test, your results, and what your doctor may do with that information. Genes are pieces of DNA that we inherit from our parents. Genes provide the instructions to make our bodies look and work as they do. Some genes affect the way medicines work in the body.

Key points about CYP3A5. CYP3A5 is part of the cytochrome P450 family of enzymes that helps the body break down certain medicines. A pharmacogenomic test can help your medical team know well your CYP3A5 enzyme will work. Some people may need a change in medicine dose based on CYP3A5 enzyme activity.

CYP3A5 is the predominant CYP3A protein in human kidneys, lungs, blood, and pituitary and is also present in liver and intestinal tissues [5,26]. CYP3A5 also shows interindividual differences—from severalfold to hundreds of times—in terms …

CYP3A, a key member of the cytochrome P450 (CYP450) superfamily, is integral to drug metabolism, processing a substantial portion of medications. Their role in drug metabolism is particularly prominent, as CYP3A4 and CYP3A5 metabolize …

Mar 28, 2025 · CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Warfarin Sensitivity. Among its related pathways are Metapathway biotransformation Phase I and II and Clomipramine Pathway, Pharmacokinetics.

Gene ID: 1577, updated on 8-Feb-2025. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of …

Mar 4, 2025 · What is the CYP3A5 gene, and why is it important? The CYP3A5 gene gives instructions for an enzyme that is important in drug metabolism. Genetic variability changes the enzyme activity and affects how people respond to drugs. Understanding the differences can help promote more personalized treatments. How does CYP3A5 affect drug metabolism?

CYP3A5 is a gene that encodes an enzyme responsible for the metabolism of more than 35% of the drugs prescribed worldwide. You might find these chapters and articles relevant to this topic. CYP3A5 is similar to CYP3A4 and metabolizes similar substrates, but its activity is diminished.

Jan 4, 2024 · Clinical resource with information about CYP3A5, An atlas of genetic influences on human blood metabolites., Essential hypertension, genetic, Tacrolimus response, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.