In humans, it is the CYP2C19 gene that encodes the CYP2C19 protein. [3][4] CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, [5] most notably the antiplatelet treatment clopidogrel (Plavix), drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the ...

The CYP2C19 gene is frequently included in different pharmacogenomic panels tested in clinical practice, due to its involvement in the metabolism of a myriad of frequently prescribed medications. Accordingly, CYP2C19 genotyping can promote precise ...

The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells in a cell structure called the endoplasmic reticulum, which is involved in protein …

May 1, 2008 · The enzyme CYP2C19 is found primarily in the liver, as are the previous enzymes we discussed (CYP1A2 and CYP2C9). CYP450 enzymes metabolize most medications, and the most important of these enzymes are CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4.

Sep 1, 2023 · CYP2C19 plays a crucial role in drug metabolism, influencing the efficacy and safety of various medications. This genetic variability among individuals can lead to significant differences in drug response, making pharmacogenetic testing an …

This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC). CYP2C19 Brief History

Jan 30, 2018 · CYP2C19 is an enzyme involved in the hydroxylation of the S form of an anti-epileptic agent mephenytoin, and also in the metabolism of a series of proton pump inhibitors such as omeprazole. The PM for CYP2C19 is found in about 20% of Japanese and about 3% of Caucasians [14].

Dec 24, 2024 · CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Major Depressive Disorder.

Feb 14, 2024 · A comprehensive examination of the role of the CYP2C19 gene in real-world medical settings is presented in this review. This review summarizes the most recent information on how genetic variants in CYP2C19 affect drug metabolism and therapeutic outcomes.

Jul 9, 2013 · CYP2C19 is a member of the IIC subfamily of the cytochrome p450 genes, responsible for metabolizing or activating some hormones (such as estrogens) and several commonly prescribed drugs, including anti-epileptics (such as diazepam, phenytoin, and phenobarbitone), anti-depressants (such as amitriptyline and clomipramine), the anti-platelet …