This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

In this review, we will provide an overview of the key players in CYP2B6 expression and function and highlight recent advances made in assessing clinical ramifications of important CYP2B6-mediated drug–drug interactions.

Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of antiretroviral, antimalarial, anticancer, and antidepressant drugs. These drug classes are commonly in use worldwide and face specific population variability in side effects and dosing.

Mar 30, 2025 · CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Major Depressive Disorder. Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II.

Mar 4, 2013 · CYP2B6 is one of the most polymorphic CYP genes in humans and variants have been shown to affect transcriptional regulation, splicing, mRNA and protein expression, and catalytic activity.

As CYP2B6 is the major enzyme involved in the metabolism of efavirenz and nevirapine, its pharmacogenomics has become relevant for the treatment of HIV. Efavirenz has a narrow therapeutic window with severe CNS side effects associated with its high plasma concentrations and treatment failure associated with low concentrations.

Cytochrome P450 2B6 (CYP2B6) is a minor isoform of CYP mixed-function oxidase family of drug-metabolizing enzymes. You might find these chapters and articles relevant to this topic. CYP2B6 is expressed in the liver and constitutes less than 1% of the total hepatic CYP content.

Gene ID: 1555, updated on 8-Feb-2025. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP2B6 is one of the most polymorphic CYP genes in humans with over 100 described SNPs, numerous complex haplotypes and distinct ethnic and racial frequencies. This review summarizes the basic properties of CYP2B6 and the main characteristics of clinical relevance.

Jan 4, 2025 · This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.