Genes encoding P450 enzymes, and the enzymes themselves, are designated with the root symbol CYP for the superfamily, followed by a number indicating the gene family, a capital letter indicating the subfamily, and another numeral for the individual gene.

Cytochrome P450 (CYP450) is a group of enzymes that play an essential role in Phase I metabolism, with 57 functional genes classified into 18 families in the human genome, of which the CYP1, CYP2, and CYP3 families are prominent.

The Cytochrome P450 Homepage is a universal resource for nomenclature and sequence information on cytochrome P450 (CYP) genes. The site has been in continuous operation since February 1995. Currently, naming information for 11,512 CYPs are available on the web pages.

The superfamily has the root symbol CYP, followed by a number to indicate the family, a capital letter for the subfamily with a numeral for the individual enzyme. Some CYP are able to metabolise multiple substrates, others are oligo- or mono- specific. CYP also catalyse diverse oxidation and reduction reactions.

Overview: The cytochrome P450 enzyme family (CYP450) were originally defined by their strong absorbance at 450 nm due to the reduced carbon monoxide-complexed heme component of the cytochromes.

Dec 8, 2000 · Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P450 genes (also called CYP) are found in the genomes of virtually all organisms, but their number has exploded in plants.

Cytochrome P450 (abbreviated CYP, P450, infrequently CYP450) is a very large and diverse superfamily of hemoproteins found in all domains of life. [1] Cytochromes P450 use a plethora of both exogenous and endogenous compounds as substrates in enzymatic reactions.

Jan 1, 2017 · Cytochrome P450 stands for a superfamily of more than 50 closely related heme-containing enzymes, which can be divided into families (with at least 40% sequence homology on the amino acid level) and subfamilies (with at least 55% sequence homology), each with their own substrate specificity.

Cytochrome-P450 system CYP450 A superfamily of heme-containing, primarily oxidative enzymes that take part in phase 1 reactions. Responsible for a large amount of drug/toxin breakdown. Alterations in CYP-activity (e.g., due to drug interactions) can cause severe shifts in drug half-life and may lead to supra- or subtherapeutic drug levels.

All human P450 genes and all P450 pseudogenes are included in this table. This table contains more than 700 links to human P450 data, including known crystal structures. CYP names in column 1 are linked to their protein sequences, including the pseudogenes. X at the end of a CYP name means that name has been discontinued and replaced by a new name.