CYP: cytochrome P450. * Mifepristone is a strong inhibitor of CYP3A4 when used chronically (eg, for hyperglycemia in patients with Cushing syndrome). The CYP3A4 inhibitory effect of a …

For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver …

The hepatic metabolism of drugs and the mechanisms by which drugs might injure the liver will be reviewed here. The different clinical patterns of drug-induced hepatotoxicity and the use of …

Coadministration of drugs that alter CYP metabolism or drug transporters often requires dose limitations or avoidance. The patient's medication list should be analyzed using a drug …

Examples of drugs that are substrates of P-gp efflux pump include: apixaban, colchicine, cyclosporine, dabigatran, digoxin, edoxaban, rivaroxaban, and tacrolimus. The degree of effect …

CYP: cytochrome P450; Pgp: P-glycoprotein efflux transporter. * The metabolism and clearance of serotonin modulators may be altered by co-administration of medications that inhibit or …

Data on metabolism may help assess potential drug interactions through alteration of CYP3A4 metabolism and/or P-gp-mediated drug efflux. Refer to the drug interactions program included …

Dec 5, 2023 · Tricyclic and tetracyclic drugs: Pharmacology, administration, and side effects; Unipolar depression in adults: Choosing treatment for resistant depression; Unipolar major …

Sep 25, 2024 · Rifamycins (most notably rifampin) are moderate to potent inducers of drugs undergoing metabolism by the cytochrome P450 enzyme system (notably CYP3A4), which …

- Cytochrome P450 3A inhibitors and inducers; RELATED TOPICS. Acquired long QT syndrome: Definitions, pathophysiology, and causes; Biology of warfarin and modulators of INR control; …