Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation. [5]

CXCL9, also known as monokine induced by gamma interferon (MIG), is located on human chromosome 4, and is induced by IFN-γ but not by IFN-α/β. CXCL10 and CXCL11 are also located on human chromosome 4. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth.

Mar 30, 2025 · CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation …

CXCL9 has a versatile and controversial role in tumors, and accumulating evidence suggests that CXCL9 is closely associated with the prognosis of tumor patients.

Jul 1, 2023 · CXCL9 participates in metabolic-associated fatty liver disease via facilitating the imbalance of Treg/Th17 cells with interferon-gamma, providing another new direction to treat this disease .

Mar 8, 2025 · Title: CXCL9 may serve as a potential biomarker for primary Sjögren's syndrome with extra-glandular manifestations. Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.

CXCL9 is a chemokine that belongs to the alpha or CXC subfamily. It is primarily involved in attracting activated T lymphocytes, particularly of the Th1 phenotype, to sites of inflammation. It is induced by the Th1-associated cytokine IFN-γ and plays a crucial role in regulating effector cell recruitment in Th1-associated diseases.

The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis).

Mar 21, 2022 · Response to immune checkpoint blockade (ICB) in ovarian cancer remains disappointing. Several studies have identified the chemokine CXCL9 as a robust prognosticator of improved survival in...

This review for the first time presents the most comprehensive summary for the role of CXCL9 in different types of tumors, and demonstrates its contradictory role of CXCL9 in tumor progression. Altogether, this is a useful resource for researchers investigating therapeutic opportunities for …