Sep 12, 2022 · CXCL13 is a chemokine that is widely involved in the pathogenesis of autoimmune diseases, tumors and inflammatory diseases. In this study, we investigate the role of CXCL13 in the pathogenesis of inflammatory bowel disease using both …

Jan 11, 2016 · CXCL13 (100 ng) induced rapid pERK expression (1 hour) in the spinal dorsal horn in WT mice, but not in Cxcr5 KO mice (Figure 8, A and B). Additionally, double-immunofluorescence staining showed high colocalization of pERK with GFAP ( Figure 8, C–F ).

005626 B6.129X1- Cxcl13 tm1Cys /J These Cxcl13 knock-out mice exhibit defective B cell organization, and are suitable for use in applications related to lymph node and Peyer's patch development.

Rainey-Barger et al. confirmed that CXCL13 deficiency leads to waning numbers of myelin-reactive Th1 and Th17 cells in the periphery of mice after peak EAE, and also showed that CXCL13 KO mice have no defects in the early recruitment of B cells into the inflamed CNS .

In this review, we focused on the sources of CXCL13 in different conditions and its regulatory mechanisms in immune-mediated inflammatory diseases, providing novel ideas for further research on targeting CXCL13 for the treatment of immune-mediated inflammatory diseases.

Jul 19, 2021 · CXCL13 promotes proliferation in androgen-responsive LNCaP cells in a JNK-dependent, DOCK2-independent manner, whereas this effect is dependent on DOCK2 in androgen-independent PC3 cells. CXCL13-mediated invasion in prostate cancer cells depends on PI3K/Akt, Src, ERK, and FAK, but it is independent of DOCK2 (121, 122).

Here, after briefly considering the known consequences of systemic deletion or neutralization of CXCL13, we focus on its role in driving inflammation in the CNS and on the potential to target the CXCL13-CXCR5 axis as a therapeutic strategy in selected neuroinflammatory disorders.

Sep 12, 2022 · CXCL13 is a chemokine that is widely involved in the pathogenesis of autoimmune diseases, tumors and inflammatory diseases. In this study, we investigate the role of CXCL13 in the pathogenesis of inflammatory bowel disease using both …

CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.

Sep 1, 2022 · Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, builds a signaling network that regulates not only normal organisms but also the development of many diseases.