The shorter p110 CUX1 isoform stably interacts with DNA and can function as transcriptional repressor or activator depending on promoter context. [43][44] Transcription and cell-based …

Jan 7, 2022 · One such protein reported to have multiple isoforms is CUT-like homeobox 1 (CUX1), a HOX-family transcription factor with critical roles in development and tumorigenesis.

The Cut homeobox gene 1 (CUX1) codes for several homeodomain proteins that display distinct DNA binding and transcriptional properties. Some CUX1 isoforms were previously shown to …

Apr 10, 2012 · Moreover, higher expression of short CUX1 isoforms, as observed in many cancers, was shown to stimulate cell migration and invasion. In parallel, elevated expression …

Jul 2, 2016 · In SSc and diffuse alveolar damage lung tissue sections, CUX1 localised within α-smooth muscle actin-positive cells. Our results suggested that CUX1 isoforms play vital roles …

In this review, we introduce the protein structures and isoforms of CUX1, describe the various biological processes in which they are involved, summarize the role of CUX1 in tumor …

Sep 5, 2014 · One CUX1 protein isoform functions as an ancillary factor in base excision repair. Other CUX1 isoforms function as transcriptional repressors or activators, depending on …

Proteolytic processing of the CUX1 transcription factor generates an isoform, p110 that accelerates entry into S phase. To identify targets of p110 CUX1 that are involved in cell cycle …

CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. The accumulated evidence supports a model of haploinsufficiency whereby …

Aug 30, 2023 · CUX1 proteins comprise long and short isoforms. The full-length p200 isoform contains four DNA binding motifs, three CUT repeats, and a homeodomain. It is proteolytically …