SHP-1 and SHP-2 in T cells: two phosphatases functioning at …
One of the best-studied inhibitory receptors is cytotoxic T-lymphocyte antigen-4 (CTLA-4) (reviewed in 133). CTLA-4 does not have ITIMs but contains two tyrosines that could provide …
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
These results indicate that recruitment of SHP-2 is induced by phosphorylation of tyrosines in the CTLA-4 signaling domain and that CTLA-4 regulates TCR signaling through SHP-2.
Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of
Mar 5, 2000 · Here, we demonstrate that the phosphorylation of CTLA-4 tyrosines (YVKM and YFIP) fails to allow for single or tandem SHP-2 SH2 domain binding. This was observed using …
Diverse Mechanisms Regulate the Surface Expression of …
Phosphorylation of CTLA-4 by Fyn and Lck recruits PI3K and SHP-2. Dephosphorylated CTLA-4 binds to AP-2 leading to the internalization of CTLA-4 to intracellular compartments such as …
Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by …
Feb 1, 1999 · CTLA-4 was found to associate with Lck and Fyn, and Lck coexpression induced the association of CTLA-4 with SHP-2. The formation of a CTLA-4 signaling complex which …
CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation
Sep 13, 2017 · SHP-2 interacts with CTLA-4 based on mutagenesis and immune coprecipitation studies. This association was suggested to be mediated by the SH2 of SHP-2 and the …
Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers …
Sep 20, 1999 · Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a T cell costimulation receptor that delivers inhibitory signals upon activation. Although the tyrosine-based motif ((165)YVKM) …
Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of
Apr 1, 2000 · Here, we demonstrate that the phosphorylation of CTLA-4 tyrosines (YVKM and YFIP) fails to allow for single or tandem SHP-2 SH2 domain binding. This was observed using …
Targeting SHP2 as a promising strategy for cancer immunotherapy
Feb 1, 2020 · SHP2 is not only a signaling molecule downstream of various immunosuppressive receptors such as PD-1, CTLA-4, BTLA and TIGIT, but also a key regulator for TCR receptor …
Molecular Basis of T Cell Inactivation by CTLA-4 | Science - AAAS
Dec 18, 1998 · Coexpression of the CTLA-4–associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRζ bound to CTLA-4 and abolished the p56 lck-inducible TCRζ–CTLA …
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