Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
Ctla-4 KO T cells develop more Th2 cells after CD3/CD28 stimulation than WT T cells, and CTLA-4-Ig treatment improves the mouse survival rate by reducing T-cell activation and proliferation …
Cytotoxic T-lymphocyte associated protein 4 - Wikipedia
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and …
Induction of autoimmune disease by deletion of CTLA-4 in mice in ...
We abrogated CTLA-4 expression in adult mice and compared their phenotype with congenitally CTLA-4–deleted mice. We found that the two modes of CTLA-4 deficiency differed in resulting …
CTLA-4 blockade drives loss of T - Nature
Feb 15, 2021 · We found that CTLA-4 blockade promotes metabolic fitness and the infiltration of immune cells, especially in glycolysis-low tumours. Accordingly, treatment with anti-CTLA-4 …
Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ (house mouse)]
Feb 8, 2025 · CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice. CTLA-4 inhibition facilitates follicular T and B cell interaction and the production of …
InVivoMAb anti-mouse CTLA-4 (CD152, Clone: 9D9) | Bio X Cell
The 9D9 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that …
Engineered ipilimumab variants that bind human and mouse CTLA-4
Jan 24, 2025 · The antibody 9D9, which binds mouse CTLA-4, is a commonly used surrogate for CTLA-4 checkpoint blockade studies in mouse cancer models. In this work, we reveal that …
Soluble CTLA-4 regulates immune homeostasis and promotes …
Mar 31, 2025 · The serum sCTLA-4 levels are reportedly correlated with the frequency of lung metastasis in a mouse melanoma model. 11 In addition, sCTLA-4-secreting effector Treg cells …
A reappraisal of CTLA-4 checkpoint blockade in cancer ... - Nature
Feb 22, 2018 · In Ctla4h/m mice expressing both human and mouse CTLA4 genes, anti-CTLA-4 antibodies that bind to human but not mouse CTLA-4 efficiently induce Treg depletion and Fc …
CTLA-4: a moving target in immunotherapy | Blood - American …
Jan 4, 2018 · Evidence from knockout mice demonstrates a more severe phenotype in complete CTLA-4 knockouts compared with Treg-specific knockouts, indicating an important role for …
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