We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL/6 mice 2 weeks after exposure to a single blast.

Repeated head impacts have been suggested to be associated with the development of the neurodegenerative disorder, chronic traumatic encephalopathy (CTE). CTE is characterized by the accumulation of hyperphosphorylated tau within the brain, with accompanying cognitive and behavioral deficits.

Our concussive mouse rTBI model showed p-Tau accumulation within the corpus callosum of the traumatized hemisphere as early as 1 week after injury with subsequent involvement of the cerebral cortex, mimicking the pathological tau progression described in human disease.

May 16, 2012 · We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL/6 mice 2 weeks after exposure to a single blast. Blast-exposed mice demonstrated phosphorylated tauopathy, myelinated axonopathy, microvasculopathy, chronic neuroinflammation, and neurodegeneration in the absence of macroscopic tissue ...

Oct 1, 2018 · The injury does not cause acute pathological changes, but leads to chronic neurodegeneration, long-term cognitive dysfunction and even chronic traumatic encephalopathy (CTE). Many existing rmTBI animal models reported uncontrollable adverse effects and long experiment period.

Goldstein and his team developed a blast neurotrauma mouse model recapitulating CTE neuropathology in mice, further highlighting the determinants of CTE and providing evidence linking blast exposure to neurophysiological impairment.

Jun 8, 2022 · Chronic traumatic encephalopathy (CTE) is a disorder with specific neuropathological characteristics that are seen in autopsied brains of decedents with histories of repetitive...

Feb 28, 2018 · CTE-induced progenitor neurons will be injected into healthy mouse models. The same behavioral tests used in aims 1 and 2 will be used to evaluate expressed symptoms. Then, the drug treatments used in aim 2 will be administered to the mice to determine if …

CTE indicates chronic traumatic encephalopathy; NFT, neurofibrillary tangle; ptau, phosphorylated tau. For all images, 10-µm paraffin-embedded tissue sections were immunostained with microscopic mouse monoclonal antibody for phosphorylated tau (AT8) (Pierce Endogen).

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease thought to be associated with a history of repetitive head impacts [1 - 8, 9••, 10, 11, 12•], such as those sustained through contact sports or military combat.