CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. [8] CRTC2 is thought to drive tumorigenesis in STK11 (LKB1)-null non-small cell lung cancers (NSCLC). [9]

Mar 30, 2025 · CRTC2 (CREB Regulated Transcription Coactivator 2) is a Protein Coding gene. Diseases associated with CRTC2 include Glycogen Storage Disease Ia and Lysosomal Storage Disease. Among its related pathways are Cellular responses to stimuli and Transcriptional activation of mitochondrial biogenesis.

Among the family members, CRTC2 has emerged as a major mediator of cAMP signaling pathways in metabolic tissues. In this review, we delineate the recent findings regarding the role of CRTC2 in metabolic homeostasis in various tissues, from studies utilizing CRTC2-knockout (KO) mouse models. IDENTIFICATION OF CRTC PROTEINS

Jul 6, 2015 · Here we show in mice that CREB regulated transcription coactivator 2 (CRTC2)6 functions as a mediator of mTOR7 signalling to modulate COPII-dependent SREBP1 processing.

CRTC2, also known as cAMP response element binding protein 2, is an important regulator of glucose metabolism. In 2008, Renaud Dentin et al. discovered o-glycosyl transferase (OGT). O-glycosylation of CRTC2 transducers triggers hepatic gluconeogenesis (Dentin et al. 2008).

It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.

Feb 9, 2025 · CRTC2 is unphosphorylated and therefore constitutively activated in LKB1-mutant non-small cell lung cance, where it promotes tumor growth, in part via the induction of the inhibitor of DNA binding 1. Results identified CRTC2 as a downstream substrate of …

CRTC2 was reported to play a key role in fasting-induced hepatic gluconeogenesis based on the following observations: (i) CRTC2 was enriched in the nuclei of hepatocytes during fasting or after exposure to cAMP-raising agents/hormones; and (ii) overexpression of CRTC2 in the liver promoted gluconeogenesis, whereas RNAi-mediated silencing of ...

We examined the effect of CRTC2 on endothelial function using a mouse aorta ring assay ex vivo and with photothrombotic stroke in endothelial cell-specific CRTC2-knock-out male mice in vivo. CRTC2 was highly expressed in endothelial cells and related to angiogenesis.

Nov 30, 2017 · Here we show that Creb regulates transcriptional co-activator (Crtc) 2 is a major regulator of whole-body energy metabolism. Crtc2 liver-specific knockout lowers blood glucose levels with...