Creb1 is the gene responsible for transcription of all known CREB isoforms; the α isoform is the most common, but the β and Δ isoforms are also transcribed. Several approaches have been used to clarify the roles of different CREB isoforms.

May 4, 2011 · To determine whether the observed increase of CREB1 in the ganglia is specifically present in the subpopulation of neurons critical for LTM, we examined the levels of CREB1 protein in isolated SNs using immunofluorescence and confocal microscopy.

Aug 6, 2024 · CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95, 211–223. doi: 10.1016/s0092-8674(00)81752-3 PubMed Abstract | Crossref Full Text | Google Scholar

Aug 26, 2015 · Dash et al. (1990) demonstrated that, during LTM in Aplysia neurons, PKA activates gene expression via CREB. They could selectively eliminate the long-term process by blocking the binding of CREB1 to its DNA response element.

These findings suggest that CREB1-mediated gene expression is required for the LTM-induced up-regulation of synaptic proteins, syntaxin-1 and dynamin-1, in L. stagnalis. Our study thus offers new insights into the molecular mechanisms that mediate CREB1-dependent long …

Mar 2, 2018 · The repressive effect of CREB2 is decreased and CREB1 activates the expression of target CRE-dependent genes required for LTM formation. It is important to note that in addition to CREB2, another member of the ATF/CREB family, CREB1 also regulates long-term synaptic plasticity and memory but it acts as a key transcriptional activator of ...

CREB1, which is homologous to mammalian CREB, is a transcription activator necessary for long term facilitation (LTF) (18, 19). Bartsch et al. (19) found that creb1 mRNA was increased in the CNS after exposure of the whole animal to serotonin (5-HT), a transmitter thought to mediate LTF.

Jun 20, 2010 · These findings suggest that CREB1-mediated gene expression is required for the LTM-induced up-regulation of synaptic proteins, syntaxin-1 and dynamin-1, in L. stagnalis. Our study thus offers new insights into the molecular mechanisms that mediate CREB1-dependent long-term memory formation.

Oct 16, 1998 · We have found a single Aplysia CREB1 gene homologous to both mammalian CREB and CREM and have characterized in the sensory neurons that mediate gill-withdrawal reflex the expression and function of the three proteins that …

Oct 2, 2019 · Here, we study the effect of different crh-1 [Caenorhabditis elegans homolog of mammalian cAMP response element binding protein 1 (CREB1)] isoforms on the ability of C. elegans to form long-term memory (LTM).