Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β). It belongs to a group …

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and immune cell modulator. Exogenous CGRP could increase the cerebral blood flow significantly and protect the ischemic neurons, but its mechanism is not entirely clear.

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 and calcitonin‑receptor‑stimulating peptide.

Together, CGRP can promote CREB entering the nucleus and phosphorylation activation, enhance mRNA transcription, and promote the expression of osteogenic factors such as BMP2 and SP7 to promote bone formation by increasing the concentration of intracellular cAMP.

Increased CGRP expression in sensory neurons is associated with inflammatory pain. We examined the molecular basis of CGRP expression and found that acid-sensing nociceptor Trpv1 is activated under inflammatory acidic environments and up-regulates the CGRP expression through CaMK-CREB cascade.

The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervention. We demonstrate here how CGRP regulates the development of morphine analgesic tolerance at the spinal level.

CGRP stimulation of four intracellular signalling molecules relevant to pain (cAMP, CREB, p38 and ERK) were examined in rat TG neurons and compared to transfected CGRP and AMY 1 receptors in Cos7 cells. In TG neurons, olcegepant displayed signal-specific differences in antagonism of CGRP responses.

One known downstream mediator of cAMP action is the transcription factor cAMP response element binding protein (CREB) (Russell et al., 2014). We observed that CREB phosphorylation was induced by CGRP and dibutyryl-cAMP but also by IL-33 and NMU (Figure 5E).

Dec 2, 2004 · Our results demonstrate that CGRP increased cAMP production, phosphorylation of CREB and CRE‐dependent gene transcription in DRG neurons, thereby documenting that CGRP receptors couple to adenylyl cyclase and regulation of …

Mar 8, 2024 · We found CGRP enhanced osteogenic differentiation of BMSCs through PKA/CREB/JUNB pathway, contributing to improved sonic hedgehog (SHH) expression, which was verified at the tendon-bone interface (TBI) in the mice with Calcrl overexpression.