Cre-Lox recombination is a site-specific recombinase technology, used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA …

A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre- loxP system and a few …

Unlock the power of the Cre/lox system for tissue-specific, inducible knockouts and advanced gene tracking in mouse models. Learn practical breeding schemes to simplify complexity, …

When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequence(s) in the offspring. These Vav1-Cre transgenic …

Here we describe how tamoxifen-dependent Cre recombinases, so-called CreER recombinases, work and how they can be used to generate time- and tissue-specific mouse mutants. The …

Apr 4, 2025 · The Cre-Lox system is a powerful tool in mouse genetics, enabling precise spatiotemporal control of gene expression and conditional knockout models. Since its …

Cre mice, also known as Cre-loxP mice, are genetically modified mice that have become an essential tool in biomedical research. These mice have been instrumental in understanding the …

The simplest Cre-lox system to generate a knockout (KO) mouse model has two components that need to be genetically engineered in the murine genome: a target sequence surrounded by …

Over the past few years many inducible and/or tissue-specific Cre mouse lines have been developed. This chapter will give a brief review of the generation of Cre-expressing mouse …

Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes …