Here we describe how tamoxifen-dependent Cre recombinases, so-called CreER recombinases, work and how they can be used to generate time- and tissue-specific mouse mutants. The …

004453 STOCK Tg(CAG-cre/Esr1*)5Amc/J These CAGGCre-ER TM mice express a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a modified mouse …

These mice are useful for lineage tracking and genetic manipulation of the tissue resident γδ T cells.

Sep 17, 2020 · Here, we assessed dosage and delivery of TAM for activation of Cre in immune cell subsets assessed longitudinally and spatially using transgenic mice with ubiquitously …

In their approach, the fusion of Cre recombinase to a mutant form of the ligand-binding domain of the human estrogen receptor (ER TAM) resulted in a tamoxifen-dependent Cre recombinase …

We address the three main issues with skeletal Cre mouse models, namely (1) Cre specificity—avoiding Cre expression in unintended cell types; (2) Cre toxicity—reducing the …

Conditional gene inactivation using Cre recombinase expressed via a tissue specific promoter/enhancer allows phenotypic analyses of selected tissues, but lacks temporal control. …

Here, we examined four different microglial CreER lines (Cx3cr1YFP-CreER (Litt), Cx3cr1CreER (Jung), P2ry12CreER, and Tmem119CreER), focusing on (1) recombination specificity, (2) …

Apr 4, 2025 · The Cre-Lox system is a powerful tool in mouse genetics, enabling precise spatiotemporal control of gene expression and conditional knockout models. Since its …

Sep 27, 2018 · Cre/ERT2 mouse models are particularly useful in vascular biology, where constitutive gene deletion often causes lethality early in development. Here, we detail the most …