Feb 1, 2002 · Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response syndrome (SIRS). Contact of the blood components with the artificial surface of the bypass circuit, ischemia–reperfusion injury, endotoxemia and operative trauma are all possible causes of SIRS.

Jan 1, 2005 · Although often remaining sub-clinical and resolving promptly at the end of CPB, in its most extreme form this inflammatory response may be associated with the development of the systemic inflammatory response syndrome (SIRS) that can often lead to major organ dysfunction (MODs) and death.

Results: In patients with SIRS extending for a period greater than 12 hours (group A), the duration of CPB, interleukin-6 (IL-6), interleukin-8 (IL-8) and WBC count after aortic declamping were significantly longer and higher than those in patients with SIRS lasting less than 12 …

Jan 2, 2023 · Cardiac surgery with cardiopulmonary bypass (CPB) is associated with intense acute systemic inflammatory response (SIRS). SIRS is an exaggerated complex defense response involving multiple cellular, humoral, metabolic pathways and endocrine systems, leading to significant morbidity and mortality.

Although often remaining sub-clinical and resolving promptly at the end of CPB, in its most extreme form this inflammatory response may be associated with the development of the systemic inflammatory response syndrome (SIRS) that can often …

Vasoplegic syndrome (VS) is a common complication following cardiovascular surgery with cardiopulmonary bypass (CPB), and its incidence varies from 5 to 44%. It is defined as a distributive form of shock due to a significant drop in vascular resistance after CPB.

May 16, 2016 · CytoSorb therapy combined with CRRT is a potentially promising new treatment approach to achieve hemodynamic stability, cytokine reduction, and improved organ function in cardiac surgery patients who develop post-CPB SIRS.

May 25, 2024 · CPB, with its non-pulsatile flow and obligatory exposure of blood to a foreign surface, predisposes to a predictable sequela of derangements affecting multiple organ systems. Most notable of these is a SIRS-like response with capillary leak syndrome and systemic vasodilation as well as multifactorial coagulopathy.

Jan 1, 2023 · Major cardiothoracic surgical procedures performed with CPB and cardioplegic arrest are associated with microvascular changes that trigger CPB-SIRS, resulting in various cascade activation.

inflammatory response may be associated with the development of the systemic inflammatory response syndrome (SIRS) that can often lead to major organ dysfunction (MODs) and death.