COS are fibroblast -like cell lines derived from monkey kidney tissue. COS cells are obtained by immortalizing CV-1 cells [1] with a version of the SV40 virus that can produce large T antigen but has a defect in genomic replication. [2]

COS cells are a type of cell line commonly used in research for producing small quantities of proteins through transient gene expression driven by SV40 large T-antigen.

One transformed cell line, COS-1, was fully characterized and found to contain the complete early region of the SV40 genome. COS-1 cells express nuclear large T and all proteins necessary for replication of appropriate circular genomes.

COS-1 and COS-7 are immortalized cell lines derived from African green monkey kidney cells (Cercopithecus aethiops). These cell lines were created by introducing Simian Virus 40 (SV40) DNA into primary kidney cells, resulting in the expression of the SV40 large T-antigen.

COS cells are monkey kidney fibroblasts (Fig. 1); they have become popular in recent years because they support certain strains of replication-deficient animal viruses and can be transfected easily.

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This unit describes the use of COS cells to efficiently produce a desired protein in a short period of time. These cells express high levels of the SV40 large tumor (T) antigen, which is necessary to initiate viral DNA replication at the SV40 origin.

One transformed cell line, COS-1, was fully characterized and found to contain the complete early region of the SV40 genome. COS-1 cells express nuclear large T and all proteins necessary for replication of appropriate circular genomes.

COS Cells CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning.

COS cells are CV-1 monkey kidney cells that have been transformed by a defective SV40 virus that can neither autonomously replicate nor form infective virus particles.