CN-716 HCl | C22H33BCl2N6O4 | CID 168445324 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

cn-716 is a novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor.

Jul 7, 2016 · Peptide boronic acids are usually not cytotoxic to Huh7 cells, which is what we observed with compound cn-716 (fig. S7). The structure presented here forms a good starting …

Feb 2, 2019 · Compound cn-716 is a previously published 4 covalent active-site inhibitor of the Zika virus NS2B-NS3 protease, which has been used in this study for comparison. Small (<2 …

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Jun 23, 2020 · In this context, we present here a comparative structural study, based on quantum chemistry calculations, to analyze the intermolecular binding energies between the …

Apr 16, 2024 · Another dipeptide endowed with the boronic acid moiety is Bz-(4-CH 2 NH 2)Phe-Arg-B(OH) 2 (CN-716, 40), which showed K i values of 0.051 and 0.04 ± 0.06 µM against …

Aug 30, 2016 · Lei et al. now report the 2.7 Å crystal structure of ZIKV protease in complex with a peptidomimetic boronic-acid inhibitor (cn-716). In the structure of the complex, the boronic acid …

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