This review aims to concisely summarize ongoing research on CMV-based vectors and discuss future applications of CMV-vectored gene therapy, with a particular emphasis on its role in vaccine vector developments.

Plasmid pCMV-GFP from Dr. Connie Cepko's lab contains the insert CMV promoter-EGFP and is published in Proc Natl Acad Sci U S A. 2004 Jan 6. 101(1):16-22. This plasmid is available through Addgene.

The intricate interaction between vector, antigen and vaccine immune response requires a comprehensive system-immunology approach and each experience with a new CMV vector as vaccine candidate contributes to the solution of this three-parts puzzle.

SnapGene Viewer is free software that allows molecular biologists to create, browse, and share richly annotated sequence files. The maps, notes, and annotations in the zip file on this page are copyrighted material.

CMVs induce the most potent CD8 + T lymphocyte response to a pathogen known in each of their hosts, maintain and even increase it for life for selected antigens, in what is known as the ever growing inflationary memory, and maintain an effector memory status due to recent and repeated antigen stimulation that endows these inflationary T lymphocy...

CMV could systematically elicit and maintain high frequencies of effector memory T cells through the “memory inflation” mechanism. Studies have shown that CMV can be genetically modified to induce distinct patterns of CD8 + T-cell responses, while some unconventional CD8 + T-cell responses are rarely induced through conventional vaccine strategies.

Jan 7, 2022 · We generated two recombinant murine CMV (MCMV) vaccine vectors expressing hemagglutinin (HA) of influenza A virus (MCMV HA) or the spike protein of severe acute respiratory syndrome coronavirus 2...

Vector with a neomycin resistance marker for expression of N-terminally 3xFLAG-tagged proteins in mammalian cells.

Oct 2, 2023 · Viral vectors have emerged as powerful tools for delivering and expressing foreign genes, playing a pivotal role in gene therapy. Among these vectors, cytomegalovirus (CMV) stands out as a promising viral vector due to its distinctive attributes including large packaging capacity, ability to achieve …

The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency, effector-differentiated, CD8 + T cells in tissues for immediate immune interception of nascent primary infection.