The Human Cytomegalovirus Major Immediate-Early Proteins as …
The CMV antagonists of proinflammatory cytokine (including type I IFN) induction and signal transduction include the IE1 and IE2 proteins. Proinflammatory cytokines and type I IFNs are …
Immediate-Early (IE) gene regulation of cytomegalovirus: IE1
In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses. Keywords: …
The Human Cytomegalovirus Major Immediate-Early Enhancer …
During productive infection, CMV genes are expressed in a temporal cascade, designated immediate-early (IE), early, or late. The human CMV IE genes include the major IE genes …
Human Cytomegalovirus IE2 Both Activates and Represses
May 17, 2022 · Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection. IE2 functions as an …
Immediate-Early (IE) gene regulation of cytomegalovirus: IE1 ... - PubMed
In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.
CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects
Mar 28, 2007 · Several new IE-1 HLA class I epitopes were identified, including 4 restricted to HLA-C antigens. One region of IE-1 spanning amino acids 300 to 327 was rich in class I …
The major immediate-early proteins IE1 and IE2 of human …
Jun 1, 1997 · Confocal double-label indirect immunofluorescence assay analysis confirmed that both IE1 and IE2 colocalized transiently with PML in punctate bodies at very early times after …
A Fusion Protein of HCMV IE1 exon4 and IE2 exon5 Stimulates …
Aug 1, 2008 · To best gauge the strength of the rMVA to stimulate CMV-specific T cells from PBMC of CMV-positives, we first examined the ex vivo recognition of the three peptide …
Human Cytomegalovirus Major Immediate Early 1 Protein Targets …
We demonstrate that the viral protein targets human nucleosomes by directly binding to core histones in a nucleic acid-independent manner. IE1 exhibits two separable histone-interacting …
Human Cytomegalovirus IE2 Both Activates and Represses …
May 17, 2022 · Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection. IE2 functions as an …