The CMV antagonists of proinflammatory cytokine (including type I IFN) induction and signal transduction include the IE1 and IE2 proteins. Proinflammatory cytokines and type I IFNs are …

The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.

The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cellular transcription. IE1 has long been …

In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses.

Aug 9, 2021 · To ensure the success of lytic replication, the herpesvirus human cytomegalovirus (HCMV) expresses the immediate-early protein IE1, which acts as an antagonist of antiviral, …

The multifunctional immediate-early protein IE1 of human cytomegalovirus directly interacts with the PML protein resulting in a disruption of the dot-like structure of PML-NBs. This review …

Jun 15, 2007 · Cytomegalovirus (CMV) infection remains a significant cause of morbidity and mortality in young children. We have previously shown that CD8+ T cell responses to CMV …

Jan 26, 2016 · Human cytomegalovirus (hCMV) immediate early 1 (IE1) protein associates with condensed chromatin of the host cell during mitosis.

Aug 1, 2008 · Both the IE1 and pp65 antigens have been made into fusion proteins and evaluated as vaccines in primary immunity models as well as stimulators of memory response using …

During productive infection, CMV genes are expressed in a temporal cascade, designated immediate-early (IE), early, or late. The human CMV IE genes include the major IE genes …