Leukocyte associated immunoglobulin-like (Ig-like) receptor 1 (LAIR-1), a ubiquitous collagen receptor expressed in many immune cell types, has been reported to interact with the CLR of …

C1q interaction with its receptor calreticulin–CD91 complex operates via CLR. This interaction enhances p38 MAPK activation, NF-κB activity and production of pro-inflammatory cytokines …

Complement component C1q, a soluble defense collagen, is the recognition protein of the classical complement pathway. C1q is able to recognize and interact with multiple targets and, …

Mar 21, 2017 · We recently demonstrated that C1q’s collagen-like region (CLR) directly engages the collagen immunoreceptor LAIR-1 (CD305) on monocytes to phosphorylate cytoplasmic …

May 12, 2021 · In this study, we provide new insights into the molecular and structural determinants underlying C1q/LAIR-1 interaction. Recombinant LAIR-1 extracellular Ig-like …

Mar 21, 2017 · Whole C1q is required to crosslink CD33 and LAIR-1 and concurrently activate CD33/LAIR-1 inhibitory motifs. While C1q binds CD33C2 domains, decreased C1q-CD33 …

Aug 31, 2020 · Complement component C1q, a soluble defense collagen, is the recognition protein of the classical complement pathway. C1q is able to recognize and interact with …

Here, we characterize variants of recombinant human C1q (rC1q) which no longer initiate complement activation, through mutation of the C1r 2 C1s 2 interaction site.

Three types of samples were analyzed to determine the PTMs of C1q: laboratory-purified C1q, commercial C1q, and CLR. Each of them was digested using successively collagenase and …

May 12, 2021 · Leukocyte associated immunoglobulin-like (Ig-like) receptor 1 (LAIR-1), a ubiquitous collagen receptor expressed in many immune cell types, has been reported to …