Dec 3, 2015 · Clinically significant CNS involvement by CLL and RS are rare conditions. Neurologic symptoms in patients with CLL are attributable to non-CLL-related etiologies in the majority of cases, even when CLL B-cells are present in the CSF.

A diagnostic lumbar puncture was performed to obtain a cerebrospinal fluid (CSF) specimen. The CSF was clear and had normal glucose and protein levels and a red blood cell count of only 2/μL but a white blood cell count of 33/μL (normal range, 0–5/μL).

Cerebrospinal fluid (CSF) was clear with normal glucose and protein levels, and negative bacterial culture. Immunophenotyping revealed the presence of lymphocytes positive for CD19, CD20weak, CD5, CD23, CD3 and CD200strong, confirming CNS infiltration by CLL cells.

Jan 1, 1996 · We have reviewed all previously reported cases of chronic lymphocytic leukemia in the CNS along with three new cases; one patient was diagnosed antemortem and treated with immediate improvement and 4-year survival.

When lymphocytosis occurs in the cerebrospi-nal fluid (CSF) of patients with lymphoma or leukemia, it is of therapeutic importance that a reactive process be distinguished from lymphom-atous infiltration of the central nervous system (CNS).

Sep 11, 2019 · CLL can rarely involve the central nervous system (CNS), either by involving brain parenchyma or cerebrospinal fluid (CSF). We present a series of three cases with clinically significant involvement of the CNS with CLL.

Central nervous system involvement (CNSi) is a rare and poorly reported complication of chronic lymphocytic leukaemia (CLL). Establishing cause and effect between the CLL and the neurological symptoms remains challenging.

Nov 11, 2016 · Suspicion of CNSi with CLL was based on persistent peripheral or central neurological symptoms associated with documentation of CLL infiltration either leptomeningeal, defined by positive cerebrospinal fluid (CSF) cytology and flow cytometry (FCM), or histopathological, defined by CNS biopsy.

Chronic lymphocytic leukemia is the most common human leukemia but infrequently causes neurologic symptoms. We have reviewed all previously reported cases of chronic lymphocytic leukemia in the CNS along with three new cases; one patient was diagnosed antemortem and treated with immediate improvemen …

Jul 10, 2024 · This article aims to analyze the diagnosis and treatment of central nervous system involvement in chronic lymphocytic leukemia. It reports two cases of central nervous system involvement in chronic lymphocytic leukemia describing the …