Aug 3, 2022 · Our findings implicate cellular dsRNA editing and sensing as a previously underappreciated mechanism of common inflammatory diseases. cis-RNA editing quantitative trait loci, which are...

Feb 7, 2020 · We unravel a binding tendency of ADARs to dsRNAs that involves GA-rich sequences for editing and splicing regulation. ADAR1 edits an intronic splicing silencer, leading to recruitment of SRSF7...

Sep 16, 2015 · With very accurate measurement of RNA editing levels at 789 sites in 131 Drosophila melanogaster strains, here we identify 545 editing QTLs (edQTLs) associated with differences in RNA editing....

Nov 1, 2015 · Here, we report a novel, sensitive and specific dsRNA reporter system for visualizing dsRNA distribution and dynamics in living cells.

We report that cis sequence effects play the largest role in modulating the editing levels between these two species, and we find that cis sequence changes promoting stability of edited dsRNA hairpins often correlate with higher editing levels.

Sep 2, 2021 · Here, we provide an overview of currently known cis- and trans-encoded sRNAs from B. subtilis with known targets and defined regulatory mechanisms and on the potential role of RNA chaperones that are or might be required to facilitate sRNA regulation in this important Gram-positive model organism.

In this Review, we describe mechanisms by which immunostimulatory dsRNAs are generated in mammalian cells, either by viruses or by the host cells, and how cells respond to them, with the focus on recent developments regarding the role of cellular dsRNAs in immune modulation.

Jan 25, 2021 · Here, we show that translation enhancement of the rice (Oryza sativa) PHOSPHATE1.2 (PHO1.2) mRNA is enabled by specific structural rearrangements guided by its noncoding antisense RNA (cis -NAT pho1.2).

Sep 26, 2023 · Recent progress in human and mouse genetics has transformed our understanding of the molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) causes...

We unravel a binding tendency of ADARs to dsRNAs that involves GA-rich sequences for editing and splicing regulation. ADAR1 edits an intronic splicing silencer, leading to recruitment of SRSF7 and repression of exon inclusion.