In this article, we will review i) eCIRP’s role in pathobiology focusing on CIRP’s induction and release, ii) eCIRP’s mechanism of action, and iii) the development of eCIRP-targeting therapeutic interventions to ameliorate inflammatory diseases. CIRP is …

Surface plasmon resonance analysis indicates that CIRP binds to the TLR4/MD2 complex as well as to individual TLR4 and MD2. The human CIRP amino-acid segment 106-125 binds to MD2 with high affinity. Collectively, CIRP is a new proinflammatory mediator of shock.

The activity of extracellular CIRP is mediated through the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex. Surface plasmon resonance analysis indicated that CIRP binds to the TLR4-MD2 complex, as well as to TLR4 and MD2 individually.

Jun 9, 2021 · We synthesized a small peptide, Trans-activating (Tat)–cold-inducible RNA binding protein (Tat-CIRP), which perturbed the function of MD2 and strongly protected neurons against excitotoxic injury in vitro.

Oct 6, 2013 · Here we report increased levels of cold-inducible RNA-binding protein (CIRP) in the blood of individuals admitted to the surgical intensive care unit with hemorrhagic shock. In animal...

Sep 16, 2021 · Downregulation of MD2 expression by AAV-shMD2 or Tat-CIRP-CMA improved the spatial reference learning and memory in animals subjected to anesthesia and surgery. Furthermore, Tat-CIRP-CMA treatment decreased the expression of membrane α5GABA A Rs and tonic currents in CA1 pyramidal

CIRP has been found in serum, where it binds the TLR4-MD2 complex, acting as a Damage-associated molecular pattern (DAMP). CIRP activates the NF-κB pathway, increasing phosphorylation of Iκκ and IκBα, and stabilizes mRNAs encoding pro-inflammatory cytokines.

Aug 1, 2020 · Cold-inducible RNA-binding protein (CIRP) was previously identified as an intracellular stress-response protein, which can respond to a variety of stress conditions by changing its expression and regulating mRNA stability through its binding site on the 3′-UTR of its targeted mRNAs.

Cold-inducible RNA-binding protein (CIRP) was previously identified as an in-tracellular stress-response protein, which can respond to a variety of stress condi-tions by changing its expression and regulating mRNA stability through its binding site on the 3′-UTR of its targeted mRNAs.

Jun 9, 2021 · We synthesized a small peptide, Trans-trans-activating (Tat)-cold-inducible RNA binding protein (Tat-CIRP), which perturbed the function of MD2 and strongly protected neurons against excitotoxic injury in vitro.