Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. [5][6][7] CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex. [8][9][10] The product of this gene belongs to the SNF2/RAD54 helicase family.

Sep 3, 2020 · CHD4 neurodevelopmental disorder (CHD4 -NDD) is associated with developmental delay, speech delay, and usually mild-to-moderate intellectual disability. Variability between individuals with CHD4 -NDD is significant, and a few have normal intelligence.

Mar 30, 2025 · CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Pallister-Hall Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and …

CHD4 is an essential and ubiquitous chromatin remodelling enzyme that until recently has received less attention than remodellers such as Snf2 and CHD1. Here we review what recent work in the field has taught us about how CHD4 reshapes the genome.

Aug 7, 2019 · In this study, we investigated the clinical spectrum of the disorder, genotype–phenotype correlations, and the effect of different missense variants on CHD4 function.

CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A. Chd4 choreographs self-antigen expression for central immune tolerance. CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.

The CHD (chromodomain helicase DNA binding protein) family consists of nine chromatin remodeling factors that alter chromatin structure in an ATP-dependent manner. CHD4 contributes to the regulation of various cellular activities and processes including development through interaction with multiple …

Dec 6, 2022 · CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters chromatin...

May 8, 2017 · CHD4 knockdown activates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion, and metastases. High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early …

Jul 9, 2020 · Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates...