Sep 20, 2022 · Distinguish mucinous bronchioloalveolar adenocarcinoma (CDX2-) from metastatic mucinous colorectal adenocarcinoma (CDX2+, Am J Clin Pathol 2004;122:421) Microscopic (histologic) images Contributed by GenomeMe

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX-2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, [5][6] playing an essential role in the development and function of the digestive system.

Jan 21, 2016 · Analysis of CDX2 messenger RNA (mRNA) expression in the NCBI-GEO discovery data set revealed the presence of a minority subgroup of CDX2-negative colon cancers that were characterized by high...

CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription factor, expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum.

The study is aimed to evaluate the diagnostic and prognostic role of the immunohistochemical expression of the Caudal-type homeobox transcription factor 2 (CDX2) in colorectal cancers (CRCs) through a meta-analysis.

Mar 30, 2025 · CDX2 (Caudal Type Homeobox 2) is a Protein Coding gene. Diseases associated with CDX2 include Anorectal Malformation and Sirenomelia. Among its related pathways are Incretin synthesis, secretion, and inactivation and Metabolism of proteins.

Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements across developmental time. Embryonic loss of CDX2 triggers homeotic transformation of intestinal fate, whereas adult-onset loss ...

CDX2 is a protein made by cells that line the inside of the gastrointestinal tract, including the small intestine and the colon. It plays an important role in controlling how these intestinal cells grow and develop.

CDX2 may be considered a sensitive and specific marker of midgut serotonin-producing /EC/-cells and EC-cell tumors, and its expression may be useful in the diagnosis of metastases from occult ETs; Cdx2 expression in invasive ductal carcinomas may be a …

Mar 20, 2025 · Cdx2 positivity is a valuable biomarker for diagnosing and classifying gastrointestinal malignancies, particularly colorectal adenocarcinomas. It is expressed in approximately 85–98% of colorectal carcinomas, making it a reliable marker for identifying tumors of intestinal origin.