Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

Mar 30, 2025 · CDKN1B (Cyclin Dependent Kinase Inhibitor 1B) is a Protein Coding gene. Diseases associated with CDKN1B include Multiple Endocrine Neoplasia, Type Iv and Primary Hyperparathyroidism. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Autodegradation of the E3 ubiquitin ligase COP1.

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division.

Recently, somatic and germline mutations in CDKN1B were also identified in patients with sporadic PHPT, lymphoma, and breast cancer, demonstrating a novel role for CDKN1B as a tumor susceptibility gene for endocrine and other neoplasms. In this review, we present the clinical and genetic characterization of the MEN4 syndrome and talk about the ...

Cyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in intervertebral disc degeneration tissue.

CDKN1B, encoding p27 Kip1, is mutated in human cancers. We demonstrate that c.25G>A (p.G9R) CDKN1B mutation, identified in a parathyroid adenoma, generates a new consensus sequence for R‐directed kinases causing p27 Kip1 phosphorylation on a residue (S12) physiologically unphosphorylated.

Feb 9, 2025 · Title: MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration, and angiogenesis by regulating CDKN1B. Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.

Feb 20, 2025 · Clinical resource with information about CDKN1B, Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians., Multiple endocrine neoplasia type 4, …

The CDKN1B gene, encoding for the CDK inhibitor p27 kip1 , is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. Lessons learned from small intestine neuroendocrine tumors suggest that CDKN1B mutations could be subclon …

CDKN1B, or p27 (KIP1), is a cyclin-dependent kinase inhibitor that blocks the cell cycle in the G0/G1 phase upon differentiation signals or cellular insult. CDKN1B also regulates cell motility and apoptosis (summary by Cuesta et al., 2009).