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See all on WikipediaCDK7 pathway - Wikipedia
An intricate network of cyclin-dependent kinases (CDKs) is organized in a pathway to ensure that each cell accurately replicates its DNA and segregates it equally between the two daughter cells. One CDK–the CDK7 complex–cannot be so easily classified. CDK7 is both a CDK-activating kinase (CAK), which … See more
CDK7 is a cyclin-dependent kinase shown to be not easily classified. CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH. See more
An entirely new perspective on CDK7 function was opened when CDK7 was identified as a subunit of transcription factor IIH (TFIIH) and shown to phosphorylate the … See more
The CDK7-cycH-MAT1 complex has been found to play a role in the differentiation of embryonic stem cells. It has been observed that the depletion of Cyclin H leads to … See more
The growth suppressor p53 has been shown to interact with cyclin H both in vitro and in vivo. Addition of wild type p53 was found to heavily downregulated CAK activity, resulting in … See more
To be active, most CDKs require not only a cyclin partner but also phosphorylation at one particular site, which corresponds to Thr161 in human CDK1, and which is located within the so … See more
Given that CDK7 is involved in two important regulation roles, it’s expected that CDK7 regulation may play a role in cancerous cells. Cells from breast cancer tumors were found to … See more
Wikipedia text under CC-BY-SA license Cdk7: a kinase at the core of transcription and in the …
Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activating kinase (CAK) for at least one other essential …
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel ... - Nature
Feb 14, 2024 · Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell …
Human TFIIH kinase CDK7 regulates transcription-associated …
CDK7 phosphorylates the RNA polymerase II (pol II) CTD and activates the P-TEFb-associated kinase, CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog …
Cyclin-dependent kinase 7 - Wikipedia
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. [5] The protein encoded by this gene is a member of the cyclin …
Transcriptional control of DNA repair networks by …
Apr 27, 2021 · CDK7 inhibition alters RNA polymerase II (RNA Pol II) and MYC association at DNA repair genes. Blocking CDK7 activity sensitizes cells to …
- Author: Bethany Veo, Etienne Danis, Angela Pierce, Dong Wang, Susan Fosmire, Kelly D. Sullivan, Molishree Jo...
- Publish Year: 2021
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TFIIH kinase CDK7 drives cell proliferation through a …
Feb 28, 2025 · How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo–electron microscopy revealed how two clinically relevant …
Cdk7: a kinase at the core of transcription and in the ... - PubMed
Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK …
In vitro and cell-based assays uncover expanded roles for the TFIIH-associated kinase CDK7, including regulation of SETD1A/B methyltransferase activity and regulation of transcription …
CDK7 controls E2F- and MYC-driven proliferative and metabolic ...
Jun 8, 2023 · CDK7 acts as a central hub for the perturbed cyclin-dependent kinase-pRb-E2F pathway in MM cells. CDK7 inhibition impairs expression of key components of the MYC …
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