A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 …
Apr 25, 2013 · Here we show that Cdk7 is a Cdk4- and Cdk6-activating kinase in human cells, required to maintain activity, not just to establish the active state, as is the case for Cdk1 and …
- Author: Miriam Merzel Schachter, Karl A. Merrick, Karl A. Merrick, Stéphane Larochelle, Alexander Hirschi, C...
- Publish Year: 2013
Other content from pubmed.ncbi.nlm.nih.govCDK7 pathway - Wikipedia
To be active, most CDKs require not only a cyclin partner but also phosphorylation at one particular site, which corresponds to Thr161 in human CDK1, and which is located within the so-called T-loop (or activation loop) of kinase subdomain VIII. CDKl, CDK2 and CDK4 all require T-loop phosphorylation for maximum activity.
The free form of CDK7-cycH-MAT1 phosphorylates the T-loops of CDK1, CDK2, CDK4 and CD…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 9 mins
The CDK-activating kinase Cdk7: Taking yes for an answer
Conclusive evidence that human Cdk7 is a bona fide CAK emerged from chemical genetics—expanding the ATP binding pocket to accommodate bulky adenine analogs that …
A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 …
The stimulatory effect of Cdk7 T-loop phosphorylation on Cdk4 activation suggested a means to boost Cdk4 activity in response to growth factors—a distinctive feature of Cdk4 regulation in …
Emerging roles of cyclin-dependent kinase 7 in health …
Oct 15, 2024 · Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of CDK-activating kinase (CAK), which phosphorylates CDK1/2/4/6 and RNA polymerase II (Pol II) to promote cell cycle progression and gene transcription, …
TFIIH kinase CDK7 drives cell proliferation through a …
Feb 28, 2025 · Selective CDK7 inhibition causes cell cycle arrest (1, 8, 9); whereas CDK7-dependent regulation of CDK1, CDK2, and/or CDK4/6 can help explain this outcome, recent studies with next-generation CDK7 inhibitors …
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Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative …
Dec 10, 2024 · The study reveals that transcription regulator cyclin-dependent kinase7 (CDK7) is a promising target to circumvent TNBC's inherent resistance to CDK4/6 inhibitors. Combining …
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel ... - Nature
Feb 14, 2024 · In this review, we provide a comprehensive summary of the latest insights into CDK7 biology and recent advancements in CDK7 inhibitor development for breast cancer …
CDK4 T172 Phosphorylation Is Central in a CDK7 …
May 30, 2013 · CDK7 is required for CDK4 activation in vivo, but this requirement is conditioned by CDK4 binding to p21, and other CDK4-activating kinases must exist to phosphorylate p21-unbound CDK4 during CDK7 inhibition. The action …
CDK7 in breast cancer: mechanisms of action and therapeutic …
Apr 11, 2024 · Notably, preclinical and clinical evidence underscores the utmost promise of targeting CDK7 in the subset of advanced HR+/HER2− breast cancer cases that have …
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