Cyclin-dependent kinase 7 - Wikipedia
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. [5] The protein encoded by this gene is a member of the cyclin …
CDK7 Gene - GeneCards | CDK7 Protein | CDK7 Antibody
Mar 30, 2025 · CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, …
Structural basis of Cdk7 activation by dual T-loop phosphorylation …
Aug 3, 2024 · Here we report the crystal structure of the human Cdk7/Cyclin H/Mat1 complex containing both T-loop phosphorylations. Whereas pT170 coordinates basic residues …
Cdk7: a kinase at the core of transcription and in the crosshairs of ...
Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK …
CDK7 pathway - Wikipedia
CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH. An intricate network of cyclin-dependent kinases (CDKs) is organized in a pathway to …
Interaction with Cyclin H/Cyclin-dependent Kinase 7 (CCNH/CDK7 ...
Mar 3, 2013 · Here we report that the cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) complex interacted with CtBP2 in vivo and in vitro. Depletion of either CCNH or CDK7 decreased …
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel ... - Nature
Feb 14, 2024 · Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell …
Emerging roles of cyclin-dependent kinase 7 in health and diseases
Oct 15, 2024 · Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of CDK-activating kinase (CAK), which phosphorylates CDK1/2/4/6 and RNA polymerase II (Pol II) to promote cell cycle …
The Mediator captures CDK7, an attractive transcriptional target in ...
Sep 13, 2021 · Recent efforts to develop small molecule inhibitors that target cyclin-dependent kinase 7 (CDK7) have suggested that CDK7 may play a critical role in mediating the …
The involvement of cyclin-dependent kinase 7 (CDK7) and 9
2 days ago · Cyclin-dependent kinases CDK7 and CDK9 are central to both transcription and cell cycle regulation. CDK7 functions as the CDK-activating kinase (CAK), essential for activating …